Mental health status of relative donors versus unrelated donors before and after hematopoietic stem cell collection

doi:10.3969/j.issn.2095-4344.2014.28.016

Abstract

Abstract:

BACKGROUND: Currently, hematopoietic stem cell transplantation mainly depends on unrelated donors. Mental state of the unrelated donors is very important to ensure the successful cell transplantation.
OBJECTIVE: To compare mental and physical health status of relative and unrelated donors during the hematopoietic stem cell collection.
METHODS: We compared the mental (Symptom Checklist-90) and physical (temperature, breath, pulse, and blood pressure) health status of relative and unrelated donors at admission, 1 day before cell collection, and 1-2 days after cell collection.
RESULTS AND CONCLUSION: At admission, there was no difference in the mental health status of relative and unrelated donors (P > 0.05), while the scores on Symptom Checklist-90 were significantly higher in the unrelated donors than the relative donors, including total score, forced, depression, anxiety, hostility, and fear (P < 0.05). The physical signs were steady in the unrelated and relative donors, but the difference in breath and systolic blood pressure was of great significance before and after cell collection in the two groups. These findings indicate that during cell collection, the unrelated donors exhibit heavier mental load than the relative donors, and psychological counseling and health guidance are necessary.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: hematopoietic stem cell transplantation, stress, psychological, fear, anxiety

CLC Number:

R394.2

Hou Yan-hong, Zhao Shu-yan, Qi Qinjiazi, Liu Li-hui, Chen Xiao-fei, Shi Bing, Zhu Ling, Xu Chen, Jia Rui-ming, Wang Wei-wei, Yang Jing, Liang Yong-qing, Tan Yi, Li Fu-xing, Ye Li-ping. Mental health status of relative donors versus unrelated donors before and after hematopoietic stem cell collection[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(28): 4524-4529.

Figures/Tables 4

References

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